Tumor volume, isocitrate dehydrogenase status, WHO grade, and histology were associated with the occurrence of domain-specific impairments.Ĭonclusions. Patients with highgrade glioma were affected more severely than patients with low-grade glioma.

The percentages of neurocognitive im pairments (–2SD) were highest forĮxecutive Functioning, Psychomotor Speed, and Memory (26.5%, 23.2%, and 19.3%, respectively). Were significantly affected at the group level.

From our cohort of glioma patients (2010-2016), 168 patients met all the inclusion criteria. We performed multivariable logistic regression analyses to investigate which factors were associated with the occurrence of cognitive impairments. Outcome measures: (1) group level: mean cognitive functioning of the study sample, and (2) individual level: the For “overall NCF” and per domain, we performed analyses at 2 different levels of We studied “overall NCF” and NCF in 5 neurocognitive domains separately. All patients had undergone neuropsychologicalĪssessment as part of routine clinical care, before awake surgery. The Reporting of Observational Studies in Epidemiology) criteria. We performed a retrospective cohort study in diffuse glioma patients according to STROBE (Strengthening We aimed to quantify NCF in glioma patients before treatmentĪnd to investigate which factors influence NCF. Both the tumorĪnd its treatment contribute to these impairments. Impairments in neurocognitive functioning (NCF) frequently occur in glioma patients. Neurology, internal address G03.232, PO Box 85500, 3508 XC Utrecht, The Netherlands contributed equally to this work.īackground. Netherlands (E.v.K., I.H.W., K.M.v.B., P.A.R., T.J.S., M.J.E.v.Z.) Helmhotz Institute, Utrecht University, The NetherlandsĬorresponding Author: Emma van Kessel, MD, University Medical Center Utrecht/Brain Center Rudolf Magnus, Department of University Medical Center Utrecht/Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, The

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